Pim kinases are important targets for hematological cancer therapy because they are involved in key cellular processes such as differentiation, proliferation, survival, apoptosis, and tumorigenesis. Here, inhibitors of Pim kinases were designed and synthesized based on an indolin-2-one scaffold. Introduction of a (1H-imidazol-5-yl)meth...
Bio-scrubbers include fixed-film or suspended microorganisms and can be used to remove gas and liquid contaminants. They often require reliable modeling due to their highly complex mechanisms. However, only a few studies have conducted mathematical modeling for bio-scrubbing processes, particularly, gas treatment using fixed-film micro...
In this study, two different wastewater treatment systems, a conventional activated sludge process and pure oxygen activated sludge process, used at a municipal wastewater treatment facility in California were investigated. Their BOD and NH₃ removal efficiencies, sludge productions, and economic efficiencies were compared. The BOD remo...
In principle, any stochastic process can be expressed in the frame of the random walk model (RWM) because it equals to the sum of its regular increments (or errors), with its initial value equal to 0. Using this intrinsic versatility of the RWM, we herein demonstrate that the RWM can serve as a useful frame for identifying the underlyi...
Establishing regional infection control units is vital for effective national infection control. Therefore, an in-depth segmentation strategy is required. The annual incidence rates of Korea national notifiable infectious diseases in 16 different regions from 2001 to 2016 were analyzed using K-means clustering. Four clusters from non-n...
Lactic acid fermentation of apple pomace was performed using Lactobacillus plantarum EJ2014 to produce gammaaminobutyric acid (GABA), in the presence of 3% MSG and 0.5% yeast extract. After fermenting for 5 days, apple pomace showed pH and acidity of 6.26 and 0.48%, respectively. Fermentation of apple pomace in the presence of wood ear...
To evaluate the depigmentation effects of Camellia sinensis water extracts (CSWEs), different extracts were topically applied to artificially hyperpigmented spots on the back skin of three brownish guinea pigs (weight: 450~500 g) induced by 1,500 mJ/cm² of ultraviolet B irradiation. The CSWEs (30 μL) were applied twice per day for 6 da...
A new morphological image processing algorithm is proposed for automatically and non-destructively analyzing the cellular structure of planar-type bioceramic foam using an optical microscope. With an abundant cell density, the cell structure can differentiate high cell volume fraction, high degree of interconnection to neighboring cell...
Our study investigated the effects of the non-disulfide cross-linking enzyme transglutaminase (TG) on depolymerized dough when mixed with caffeic acid (CA) or endo-xylanase (XY). Both CA and XY significantly decreased the resistance to extension (Rmax) of the dough and increased its extensibility (E value). The reduced Rmax and increas...
Assessment of the influence is an important part of regression diagnostics. The measure of influence in linear regression has been extended to nonlinear regression. The connections between measures of influence and leverage are explored. We suggest a modification of the influence measure for assessing the influential observations on th...
Investors have long sought to manage losses when they construct portfolios in a given investment environment. It has been particularly crucial for institutional investors, such as pension funds, to manage downside risks because they are often exposed to risks inherent in establishing strategic asset allocations over a long-term investm...
For the data exhibiting a dependency structure, the exact likelihood is rarely available to researchers mainly because of unobserved initial values and unknown innovation distributions. It is the case in practice to assume a tractable score for the data for the sake of easy analysis. The adopted tractable score is referred to as the in...
Current literature on neural connectivity and dynamics, or equivalently, structure and function, is systemically reviewed in the current article. Based on fMRI data, I have specifically discussed how changes in the connectivity of a neural network affect the spatiotemporal network dynamics qualitatively. I have also considered local dy...
Over the past decades, there has been considerable interest in applying statistical machine learning methods in survival analysis. Ensemble based approaches, especially random survival forests, have been developed in a variety of contexts due to their high precision and non-parametric nature. This article aims to provide a timely revie...
