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cisplatin이 들어가서 crosslink 형성
3) strand breaks
IV. Evaluation
1. Selection of Test Systems
- mutagenesis test가 three tier 내에서 수행되야 함
1) tier I : the Salmonella/microsome gene-mutation test
a mammalian cell gene-mutation test
a mammalian cell chromosomal breakage test
tier I의 2개
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