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목차
1. Introduction
2. Pharmaceutical biochemistry
3. MB and amyloid plagues
4. MB and neurofibrillary tangles
5. MB and the cholinergic system
6. MB and the serotonergic system
7. MB and the glutamatergic system
8. MB and mitochondrial function
9. Conclusion
References
2. Pharmaceutical biochemistry
3. MB and amyloid plagues
4. MB and neurofibrillary tangles
5. MB and the cholinergic system
6. MB and the serotonergic system
7. MB and the glutamatergic system
8. MB and mitochondrial function
9. Conclusion
References
본문내용
ndogenous nitric oxide decreases hippocampal
levels of serotonin and dopamine in vivo. Br J Pharmacol 2000; 130:5750.
[66] Oxenkrug GF, Saβlin SO, Requintina PJ. Effect of methylene blue and related redox dyes on monoamine oxidase activity; rat pineal content of N-acetylserotonin, melatonin, and related indoles; and righting reflex in melatoninprimed frogs. Ann N Y Acad Sci 2007;1122:2452.
[67] Gillman PK. Methylene blue implicated in potentially fatal serotonin toxicity. Anaesthesia 2006;61:1013.
[68] Gillman PK. Methylene blue is a potent monoamine oxidase inhibitor. Can J Anaesth 2008;55:311.
[69] Khavandi A, Whitaker J, Gonna H. Serotonin toxicity precipitated by concomitant use of citalopram and methylene blue. Med J Aust 2008;189:534.
[70] Boyer EW, Shannon M. The serotonin syndrome. N Engl JMed 2005;352:1112. 20.
[71] Parlow JL, van Vlymen JM. The methylene blues: anticipating adverse reactions to non-anesthetic drugs. Can J Anaesth 2008;55:1.
[72] Vutskits L, Briner A, Klauser P, Gascon E, Dayer AG, Kiss JZ, et al. Adverse effects of methylene blue on the central nervous system. Anesthesiology 2008;108:6842.
[73] Martinez Jr JL, Jensen RA, Vasquez BJ, McGuinness T, McGaugh JL. Methylene blue alters retention of inhibitory avoidance responses. Physiol Psychol 1978;6:3870.
[74] Callaway NL, Riha PD, Bruchey AK,Munshi Z, Gonzalez-Lima F.Methylene blue improves brain oxidative metaβolism and memory retention in rats. Pharmacol Biochem Behav 2004;77:1751.
[75] Gonzalez-Lima F, Bruchey AK. Extinction memory improvement by the metaβolic
enhancer methylene blue. Learn Mem 2004;11:6330.
[76] Wrubel KM, Riha PD,Maldonado MA,McCollum D, Gonzalez-Lima F. The brain metaβolic enhancer methylene blue improves discrimination learning in rats. Pharmacol Biochem Behav 2007;86:712.
[77] Pratico D. Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal. Trends Pharmacol Sci 2008;29:6095.
[78] Hassan HM, Fridovich I. Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds. Arch Biochem Biophys 1979;196:3855.
[79] Visarius TM, Stucki JW, Lauterburg BH. Stimulation of respiration by methylene blue in rat liver mitochondria. FEBS Lett 1997;412:1570.
[80] Kelner MJ, Bagnell R, Hale B, Alexander NM. Potential of methylene blue to block oxygen radical generation in reperfusion injury. Basic Life Sci 1988;49:895.
[81] Salaris SC, Baβbs CF, Voorhees WD. Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury. Biochem Pharmacol 1991; 42:49906.
[82] Zhang X, Rojas JC, Gonzalez-Lima F. Methylene blue prevents neurodegeneration caused by rotenone in the retina. Neurotox Res 2006;9:477.
[83] Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, et al. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J 2008;22:7032.
Metylene Blue의 새로운 의학적 활용: Alzheimer's disease
지도교수:
levels of serotonin and dopamine in vivo. Br J Pharmacol 2000; 130:5750.
[66] Oxenkrug GF, Saβlin SO, Requintina PJ. Effect of methylene blue and related redox dyes on monoamine oxidase activity; rat pineal content of N-acetylserotonin, melatonin, and related indoles; and righting reflex in melatoninprimed frogs. Ann N Y Acad Sci 2007;1122:2452.
[67] Gillman PK. Methylene blue implicated in potentially fatal serotonin toxicity. Anaesthesia 2006;61:1013.
[68] Gillman PK. Methylene blue is a potent monoamine oxidase inhibitor. Can J Anaesth 2008;55:311.
[69] Khavandi A, Whitaker J, Gonna H. Serotonin toxicity precipitated by concomitant use of citalopram and methylene blue. Med J Aust 2008;189:534.
[70] Boyer EW, Shannon M. The serotonin syndrome. N Engl JMed 2005;352:1112. 20.
[71] Parlow JL, van Vlymen JM. The methylene blues: anticipating adverse reactions to non-anesthetic drugs. Can J Anaesth 2008;55:1.
[72] Vutskits L, Briner A, Klauser P, Gascon E, Dayer AG, Kiss JZ, et al. Adverse effects of methylene blue on the central nervous system. Anesthesiology 2008;108:6842.
[73] Martinez Jr JL, Jensen RA, Vasquez BJ, McGuinness T, McGaugh JL. Methylene blue alters retention of inhibitory avoidance responses. Physiol Psychol 1978;6:3870.
[74] Callaway NL, Riha PD, Bruchey AK,Munshi Z, Gonzalez-Lima F.Methylene blue improves brain oxidative metaβolism and memory retention in rats. Pharmacol Biochem Behav 2004;77:1751.
[75] Gonzalez-Lima F, Bruchey AK. Extinction memory improvement by the metaβolic
enhancer methylene blue. Learn Mem 2004;11:6330.
[76] Wrubel KM, Riha PD,Maldonado MA,McCollum D, Gonzalez-Lima F. The brain metaβolic enhancer methylene blue improves discrimination learning in rats. Pharmacol Biochem Behav 2007;86:712.
[77] Pratico D. Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal. Trends Pharmacol Sci 2008;29:6095.
[78] Hassan HM, Fridovich I. Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds. Arch Biochem Biophys 1979;196:3855.
[79] Visarius TM, Stucki JW, Lauterburg BH. Stimulation of respiration by methylene blue in rat liver mitochondria. FEBS Lett 1997;412:1570.
[80] Kelner MJ, Bagnell R, Hale B, Alexander NM. Potential of methylene blue to block oxygen radical generation in reperfusion injury. Basic Life Sci 1988;49:895.
[81] Salaris SC, Baβbs CF, Voorhees WD. Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury. Biochem Pharmacol 1991; 42:49906.
[82] Zhang X, Rojas JC, Gonzalez-Lima F. Methylene blue prevents neurodegeneration caused by rotenone in the retina. Neurotox Res 2006;9:477.
[83] Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, et al. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB J 2008;22:7032.
Metylene Blue의 새로운 의학적 활용: Alzheimer's disease
지도교수:
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- 등록일2011.12.08
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