당뇨병의 병인 중 베타세포 기능부전의 5단계 (5 stages of evolving beta cell dysfunction during diabetes development)

소개글

당뇨병의 병인 중 베타세포 기능부전의 5단계 (5 stages of evolving beta cell dysfunction during diabetes development)에 대한 보고서 자료입니다.

목차

Progression to diabetes
1) Very beginning
2) IFG or IGT range
3) Frank diabetes

5 stage during development of DM by the authors
Stage 1 (compensation)
Stage 2 (stable period of b cell adaptation)
Stage 3
Stage 4
Stage 5

Stage 1; compensation
Signal leading to increased b cell mass
Glucokinase in b cell
The importance of b cell differentiation
Glut2
aerobic glycolysis
To maintain specialization
Some enzyme to be supressed
Include
Maintenance of b cell differentiation during stage 1 compensation

Stage 2; stable adaptation
Loss of GSIS in stage 2; glucotoxicity hypothesis
Changes in b cell differentiation in stage 2

why is stage 3 unstable?
Stage 3; unstable early decompensation

stage 4; stable decompensation
Change in b cell mass, function, and differentiation in stage 4

stage 5; severe decompensation

본문내용

Progression to diabetes
1) Very beginning
- fasting plasma glucose
; 80mg/dL -> 89 mg/dL
- cannot be recognized as clinically
2) IFG or IGT range
3) Frank diabetes
very similar change can occur as type 1 dM unfold, or as pancreatic islet cell transplantations fail
5 stage during development of DM by the authors
5 stage can be distinguished by change in b cell mass, phenotype, function
Stage 1 (compensation)
; insulin secretion increase to maintain normal glucose level during insulin resistance
2) Stage 2 (stable period of b cell adaptation)
; when glucose level rise to levels of 89 ~ 116mg/dll

키워드

diabetes,   당뇨,   당뇨의 발병,   베타 세포 기능 부전,   beta cell dysfunction,   파워포인트,   내분비 내과,   내과