동서의학과 질병관리 - 과다콜레스테롤[Hypercholesterolemia]에 관해

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동서의학과 질병관리 - 과다콜레스테롤[Hypercholesterolemia]에 관해에 대한 보고서 자료입니다.

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ion of aortas (in figure C and F)
-Figure A is the picture of aortas after staining. Orange colored-region shows atherosclerosis(아테롬성 동맥 경화증). After treatment with the nLacZ, atherosclerosis became more extensive, which can be supported by wide orange region in the picture. In contrast, treatment with the mLDLR vector led to a regression of atherosclerosis.
-Figure B shows the percent of aorta stained.
In the second method, total lesion area was quantified in the aortic root.
This analysis revealed the same overall trends, with nLacZ injected mice showing a progression, while mLDLR injected mice demonstrating a huge regression in lesion compared with baseline mice.
-In summary, both length of the aortas in first method and cross-section of aortas in second method showed marked regression of atherosclerotic lesion after mLDLR injection.
5. Treatment
5-1. Heterozygous FH
* Stains
-inhibit the enzyme HMG-CoA-reductase in the liver
⇒ the liver produces more LDLR
* Clofibrate, Probucol, Thyroxine
-prior to the statins
-reduce LDL levels
5-2. Homozygous FH
Homozygous FH is harder to treat. The LDL receptors are minimally functional. Only high doses of statins, often in combination with other medications, are modestly effective in improving lipid levels.
If medical therapy is not successful at reducing cholesterol levels, LDL apheresis may be used; this filters LDL from the bloodstream in a process similar to dialysis. The figure in the slide shows the process of LDL apheresis

키워드

동서의학과 질병관리,   과다콜레스테롤,   Hypercholesterolemia