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article(SRP): proteins secretion
* posttranslational modification: peptidase에 의한 signal sequence 제거 1. Gene
2. DNA
3. Genetic Material
4. DNA replication
5. RNA synthesis
6. RNA processing
7. Protein Synthesis
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RNA primer가 제공하는 3’-OH에 nucleoside triphosphate 를 붙여서 새로운 DNA strand를 1.STRUCTURE AND FUNCTION OF THE GENETIC MATERIAL
1) 용어 정리
2) The flow of genetic information
3) DNA replication
4) RNA and protein synthesis
2.THE REGULATION OF BACTERIAL GENE EXPRESSION
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Transcription (전사) - 원생생물의 전사
전사 조절 :
- 유전자 발현의 조절
생존에 필요한 대사조절 및 기능 단백질 합성
complex and highly regulated
대장균 내 100개 이상의 transcription factor 존재하여 RNAP 기능 조절
RNA Synthesis
1) Initiation :
- i
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RNA. Ribosomes can’t bind to this, so the mRNA is not translated, and the gene is effectively “switched off”.
13.Gene Synthesis
It is possible to chemically synthesise a gene in the lab by laboriously joining nucleotides together in the correct order. Automated machines can now make this much easier
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구조
* alpha helix
* beta sheet
* 유전암호genetic code
* tRNA (transfer RNA)
* 리보솜ribosome (80S-4,200,000Da in eucaryotes)
* aminoacyl-tRNA의 형성 (아미노산의 활성화)
* 개시복합체initiation complex의 형성
* polypeptide chain의 신장
* 합성의 종결
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