목차
그림․표 목차 .............................................................5
요 약 .............................................................6
서 론 .............................................................8
본 론
1. 우레아제(urease): 효소작용과 구조 .............................................9
2. 우레아제의 유전적특징 .............................................12
3. NixA와 니켈 수송 .............................................13
4. NikR의 조절기작 .............................................15
5. 우레아 이용성과 UreI ............................................19
결 론 ............................................................21
고 찰 ............................................................21
인용문헌 ............................................................22
요 약 .............................................................6
서 론 .............................................................8
본 론
1. 우레아제(urease): 효소작용과 구조 .............................................9
2. 우레아제의 유전적특징 .............................................12
3. NixA와 니켈 수송 .............................................13
4. NikR의 조절기작 .............................................15
5. 우레아 이용성과 UreI ............................................19
결 론 ............................................................21
고 찰 ............................................................21
인용문헌 ............................................................22
본문내용
ut 40, 25-30.
6. Benoit, S., Maier, R.J., 2003. Dependence of Helicobacter pylori urease activity on the nickel-sequestering ability of the UreE accessory protein. J. Bacteriol. 185, 4787-4795.
7. Bury-Mone', S., Skouloubris, S., Labigne, A., De Reuse, H., 2001a. The Helicobacter pylori UreⅠ protein: role in adaptation to acidity and identification of residues essential for its activity and for activation. Mol. Microbiol. 42, 1021-1034.
8. Clyne, M., Labigne, A., Drumm, B., 1995. Helicobacter pylori requires an environment to survive in the presence of urea. Infect. Immun. 63, 1669-1673.
9. Contreras, M., Thiberge, J.-M., Mandrand-Berthelot, M.-A., Labigne,A., 2003. Characterization of the roles of NikR, a nickel-responsive pleitropic autoregulator of helicobacter pylori. Mol. Microbiol. 49, 947-963.
10. Eaton, K.A., Krakowka, S., 1994. Effect of gastric pH on urease-dependent colonization of gnotobiotic pignets by Helicobacter pylori. Infect. Immun. 62, 3604-3607.
11. Fulkerson Jr., J.F., Garner, R.M., Mobley, H.L., 1998. Conserved residues and Motifs in the NixA protein of Helicobacter pylori are critical for the high affinity transport of nickel ions. J. Biol.Chem. 273, 235-241.
12. Garner, R.M., Fullkerson Jr., J., Mobley, H.L., 1998. Helicobacter pylori glutmine synthetase lacks features associated with transcriptional and posttranslational regulation. Infect. Immun. 66, 1839-1847.
13. Harry, L.T. Mobley, George L. Mendz, Stuart L. Hazell, 2001. Helicobacter pylori -Physiology and Genetics-. 1st ed., pp172-192, American Society for Microbiology. Washington, DC.
14. Kang, N.S., 2000. The effect of Helicobacter Pylori cytotoxin VacA on gastric epithelial cell growth and apoptosis. Pham. Sungkyunkwan Univ., Suwon
15. Kerstin, S., Hilde, D.R., 2005. Staying alive overdosed: How does Helicobacter pylori control urease activity?, Institut Pasteur, France
16. Schreiber, S., Konradt, M., Groll, C., Scheid, P., Hanauer, G., Werling, H.-O., Josenhans, C., Suerbaum, S., 2004. The spatial orientation of Helicobacter pylori in the gastric mucus. Proc. Natl. Acad. Sci USA 101, 5024-5029.
17. Sommi, P., Ricci, V., Fiocca, R., Romano, M., Ivey, K.J., Cova, E., Solcia, E., Ventura, U., 1996. Significance of ammonia in the genesis of gastric epithelial lesions induced by Helicobacter pylori: an in vitro study with different bacterial strains and urea concentration. Digestion 57, 299-304.
18. van Vliet, A.H.M., Poppelaars, S.W., Davies, B.J., Stoof, J.,Bereswill, S., Kist, M., Penn, C.W., Kuipers, E., Kusters, J.G., 2002. NikR mediates nickel-responsive transcriptional induction of urease in helicobacter pylori. Infect. Immun. 70, 2846-2852.
19. Weeks, D.L., Sachs, G., 2001. Sites of pH regulation of the urea channel of Helicobacter pylori. Mol. Microbiol. 40, 1249-1259.
20. Weeks, D.L. Eskandari, S., Scott, D.R., Sachs, G., 2000. A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science 287, 482-285.
6. Benoit, S., Maier, R.J., 2003. Dependence of Helicobacter pylori urease activity on the nickel-sequestering ability of the UreE accessory protein. J. Bacteriol. 185, 4787-4795.
7. Bury-Mone', S., Skouloubris, S., Labigne, A., De Reuse, H., 2001a. The Helicobacter pylori UreⅠ protein: role in adaptation to acidity and identification of residues essential for its activity and for activation. Mol. Microbiol. 42, 1021-1034.
8. Clyne, M., Labigne, A., Drumm, B., 1995. Helicobacter pylori requires an environment to survive in the presence of urea. Infect. Immun. 63, 1669-1673.
9. Contreras, M., Thiberge, J.-M., Mandrand-Berthelot, M.-A., Labigne,A., 2003. Characterization of the roles of NikR, a nickel-responsive pleitropic autoregulator of helicobacter pylori. Mol. Microbiol. 49, 947-963.
10. Eaton, K.A., Krakowka, S., 1994. Effect of gastric pH on urease-dependent colonization of gnotobiotic pignets by Helicobacter pylori. Infect. Immun. 62, 3604-3607.
11. Fulkerson Jr., J.F., Garner, R.M., Mobley, H.L., 1998. Conserved residues and Motifs in the NixA protein of Helicobacter pylori are critical for the high affinity transport of nickel ions. J. Biol.Chem. 273, 235-241.
12. Garner, R.M., Fullkerson Jr., J., Mobley, H.L., 1998. Helicobacter pylori glutmine synthetase lacks features associated with transcriptional and posttranslational regulation. Infect. Immun. 66, 1839-1847.
13. Harry, L.T. Mobley, George L. Mendz, Stuart L. Hazell, 2001. Helicobacter pylori -Physiology and Genetics-. 1st ed., pp172-192, American Society for Microbiology. Washington, DC.
14. Kang, N.S., 2000. The effect of Helicobacter Pylori cytotoxin VacA on gastric epithelial cell growth and apoptosis. Pham. Sungkyunkwan Univ., Suwon
15. Kerstin, S., Hilde, D.R., 2005. Staying alive overdosed: How does Helicobacter pylori control urease activity?, Institut Pasteur, France
16. Schreiber, S., Konradt, M., Groll, C., Scheid, P., Hanauer, G., Werling, H.-O., Josenhans, C., Suerbaum, S., 2004. The spatial orientation of Helicobacter pylori in the gastric mucus. Proc. Natl. Acad. Sci USA 101, 5024-5029.
17. Sommi, P., Ricci, V., Fiocca, R., Romano, M., Ivey, K.J., Cova, E., Solcia, E., Ventura, U., 1996. Significance of ammonia in the genesis of gastric epithelial lesions induced by Helicobacter pylori: an in vitro study with different bacterial strains and urea concentration. Digestion 57, 299-304.
18. van Vliet, A.H.M., Poppelaars, S.W., Davies, B.J., Stoof, J.,Bereswill, S., Kist, M., Penn, C.W., Kuipers, E., Kusters, J.G., 2002. NikR mediates nickel-responsive transcriptional induction of urease in helicobacter pylori. Infect. Immun. 70, 2846-2852.
19. Weeks, D.L., Sachs, G., 2001. Sites of pH regulation of the urea channel of Helicobacter pylori. Mol. Microbiol. 40, 1249-1259.
20. Weeks, D.L. Eskandari, S., Scott, D.R., Sachs, G., 2000. A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science 287, 482-285.
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