렙틴과 운동

목차

Ⅰ. 서 론

Ⅱ. 본 론
1. 렙틴의 발견과 기전
2. 렙틴과 운동
3. 렙틴과 다른 호르몬 관계
4. 렙틴과 체지방
5. 렙틴의 남녀차이

Ⅲ. 결 론

참고문헌

본문내용

167-179.
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ABSTRACT
Leptin and Exercise
Chang, Seok-Am Kim, Chang-Hwan Tchai, Esther
The discovery of a "fat-melting hormone" named leptin, which is secreted by adipocytes into the general circulation, where it helps to regulate body mass by playing a role in a feedback loop between adipocytes and the hypothalamus. For example, in ob/ob mice which do not produce a functional leptin protein, administration of leptin decrease energy intake and increases energy expenditure, resulting in weight loss. Such a loop system comprises, at present, one hypothalamic neuropeptide, namely neuropeptide Y(NPY) and on hormone leptin.
In normal animals, the impact of increased hypothalamic NPY levels appears to increase food intake and body weight gain. In obese animals, the loop system linking the brain and the periphery is altered. In the obese gene product, leptin, is neither synthesized nor secreted; leptinemia is thus nil. Hypothalamic receptots of the ob/ob mouse are normal but unoccupied as no leptin circulates in the blood. No feedback inhibition on brain NPY levels by leptin is present and NPY concentrations remain high, thereby maintaining hyperphagia, hyperinsulinemia, hypercorticism and the metabolic consequences thereof.
Regular exercise in showed that physical training resulted in decreased leptin concentrations, although in one study this occured in men but not inwomen, another study physical training lowed leptin concentrations in women but not in men and the other study physical training no changed leptin concentrations.
Leptin concentrations were closely correlated with subcutaneous adipose tissue and HPA axis.
Future areas of research intrest include activation or modulation of leptin receptors and overcomming leptin resistance with high pharmacological doses of leptin or its congeners. All of these objectives are still somewhat elusive, and a lot of research needs to be weaved together to achive them. Until then, time-honored remedies of energy restriction and regular physical exercise should be widely preached and practiced.

키워드

렙틴,   제지방,   운동