확장성 심근병증 환자의 심근에서의미토콘드리아 DNA 돌연변이

목차

1. 서론

2. 연구목적

3. 연구재료 및 방법

4. 연구성적

5. 고 찰

6. 결론

본문내용

etion/total
deletion/total
deletion/total
11-20
2/3
0/3
0/0
21-30
4/4
0/4
1/3
31-40
3/4
2/4
1/4
41-50
3/4
2/4
2/3
51-
4/5
3/5
1/2
2-2. 5.0 kb deletion
site
Age
Left ventricle
Rright ventricle
Left atrium
deletion/total
deletion/total
deletion/total
11-20
0/2
0/3
2/2
21-30
0/4
0/3
2/3
31-40
2/3
1/3
2/3
41-50
2/3
0/3
3/3
51-
4/5
4/5
1/2
Table 3. Analysis of 7.4 kb deletion according to age group in the left ventricle and right ventricle of the patients with congestive heart failure.
3-1. Left ventricle
group
Age
deletion positive
deletion negative
under 30
6
1
over 30
10
3
p value=1.0
3-2. Right ventricle
deletion positive
deletion negative
under 30
0
7
over 30
7
6
p value <0.001
Table 4. Analysis of 5.0 kb deletion according to age group in the left ventricle and right ventricle of the patients with congestive heart failure.
4-1. Left ventricle
Group
Age
deletion positive
deletion negative
under 30
0
6
over 30
8
3
p value <0.001
4-2. Right ventricle
group
Age
deletion positive
deletion negative
under 30
0
6
over 30
5
6
p value <0.001
Table 5. Analysis of 7.4 kb and 5.0 kb deletion according to chamber in all patients with congestive heart failure and 7.4 kb deletion in heart failure patients of the age under 30.
5-1. 7.4 kb deletion (total)
deletion positive
deletion negative
Left ventricle
16
4
Right ventricle
7
13
p value <0.001
5-2. 7.4 kb deletion (under 30)
deletion positive
deletion negative
Left ventricle
6
1
Right ventricle
0
7
p value<0.001
5-3. 5.0 kb deletion (total)
deletion positive
deletion negative
Left ventricle
8
9
Right ventricle
5
12
p value=0.48
Table 6. Analysis of 7.4 kb and 5.0 deletion according to age in the left atrium of the patients with congestive heart failure.
6-1. 7.4 kb deletion
Group
Age
deletion positive
deletion negative
under 30
1
2
over 30
4
5
p value < 0.001
6-2. 5.0 kb deletion
Group
Age
deletion positive
deletion negative
under 30
4
1
over 30
6
2
p value = 1.0
Table 7. Analysis of 7.4 kb deletion according to age group in the left ventricle and right ventricle of the patients with dilated cardiomyopathy.
7-1. Left ventricle
Group
Age
deletion positive
deletion negative
under 30
4
0
over 30
8
2
p value=1.0
7-2. Right ventricle
Group
Age
deletion positive
deletion negative
under 30
0
4
over 30
5
4
p value=0.104
Table 8. Analysis of 5.0 kb deletion according to age group in the left ventricle and right ventricle of the patients with dilated cardiomyopathy.
8-1. Left ventricle
Group
Age
deletion positive
deletion negative
under 30
0
4
over 30
8
3
p value=0.025
8-2. Right ventricle
Group
Age
deletion positive
deletion negative
under 30
0
4
over 30
6
3
p value=0.0699
Talbe 9. Analysis of 7.4 kb and 5.0 kb deletion according to chamber in patients with dilated cardiomyopathy.
9-1. 7.4 kb deletion
Group
Age
deletion positive
deletion negative
Left ventricle
12
2
Right ventricle
5
9
p value=0.006
9-2. 5.0 kb deletion
Group
Age
deletion positive
deletion negative
Left ventricle
8
7
Right ventricle
6
7
p value=0.48

키워드

심부전,   확장성 심근증,   미토콘드리아DNA,   결손변이,   확장성,   좌심실