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ismatch-bound MutS ATPase, GATC-bound MutH endonuclese와 appropriate exonuclease사이의 연관성을 통해 repair
- MutHLS coupling은 ATP-dependent 이고 이들은 protein-DNA translocation에 영향줌
3.2.2 Human strand-specific mismatch repair
- MutHLS system과 유사
- mismatch correction system은 strand-s
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proteins
in the cytoplasm and assists proteasome-mediated glycoprotein
degradation by forming a complex with 26S proteasome
through DNA repair protein, yRad23. Here, we describe the crystal
structures of a yPNGase and XPC-binding domain of yRad23
(yRad23XBD, residues 238–309) complex and
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단백질
전망
Ⅴ. Rb
What is Retinoblastoma(망막아세포종)?
Signs & Symptoms of Rb
Genetics of Rb
If a parent had bilateral retinoblastoma
If a parent had unilateral retinoblastoma
Rb와 cell cycle
Rb pathway와 Cancer
어떻게 Rb의 소실이 tumor를 형성하는가?
Rb의 소실만으
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2006) Association of the PDCD5 Locus With Lung Cancer Risk and Prognosis in Smokers.
Journal of Clinical Oncology vol.24: 1672-1678
6) Xuemei Z, Xiaoping M, Gang L, Bingtao H, Yonggang W, Wen T, Yi L, Yongli G, Fuchu H, Qingyi W and Dongxin L (2005) Polymorphisms in DNA Base Excision Repair Genes AD
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단백질
1. DNA ligase
2. Primase : RNA leader 서열의 합성
3. Single strand DNA binding protein(SSB) : Template의 최적구조 유지
4. Helicase : 분기점 앞 DNA의 풀림
Ⅴ. DNA복제의 실제
1. 복제분기에서의 단편
2. 단편의 검출
3. 전구체 단편의 RNA 말단
4. 전구체
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