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telomere
consist of simple tandemly repeated TTAGGG sequences and telomere-associated proteins.
telomerase
a unique ribonucleoprotein complex that is essential for telomere maintenance.
two essential core components
TERT (telomerase reverse transcriptase)
the catalytic protein component
TR (
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Sci USA 1988, 85:6622-6626.
2. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL,
Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific
association of human telomerase activity with immortal cells and
cancer. Science 1994, 266:2011-2015.
3. Colgin LM, Wilkinson C, Englezou A, Kilian A, Rob
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