본문내용
ealed(29days-)
EKG
hyperacute T wave→ST elevation→Q wave→T wave inversion→ST stable
(non Q wave MI(일부): vary in magnitude and even appear only transiently, depending on the reperfusion status of ischemic myocardiu, and restoration of transmembrane potential. not develop Q wave when obstruction thrombus is not totally occlusive, obstruction is transient, rich collateral network)
serum cardiac biomarkers
*necrotic heart muscle에서 나옴(gold standard of myocardial necrosis detection)
*detectable in the peripheral blood once capacity of the cardiac lymphatics to clear the interstitium of the infarct zone is exceeded and spillover into the venous circulation occurs(1-12시간의 지연)
1. cTnT(cardiac-specific troponin), cTnI(cardiac-specific troponin I)
skeleton muscle의 amino sequence와 달라 특이도 높다.
정상인에서는 검출되지 않으나 >20times higher in STEMI
UA from NSTEMI진단에도 사용(small MI, sleletal muscle injury)
STEMI 이후 7-10일 동안 지속
2. CK(creatine phosphokinase)
rises within 4-8h, generally returns to normal by 47-72h
특이도 낮다(skeletal muscle dz or trauma에서 증가)
CK-MB isoenzyme: significant concentrations in extracardiac tissue(특이도높다)
CK-MB2(심근):CK-MB1>1.5일 때 AMI를 시사(onset 후 2시간부터 검출, 4-6h까지 MI diagnosis 민감도, 특이도 높다)
EKG
hyperacute T wave→ST elevation→Q wave→T wave inversion→ST stable
(non Q wave MI(일부): vary in magnitude and even appear only transiently, depending on the reperfusion status of ischemic myocardiu, and restoration of transmembrane potential. not develop Q wave when obstruction thrombus is not totally occlusive, obstruction is transient, rich collateral network)
serum cardiac biomarkers
*necrotic heart muscle에서 나옴(gold standard of myocardial necrosis detection)
*detectable in the peripheral blood once capacity of the cardiac lymphatics to clear the interstitium of the infarct zone is exceeded and spillover into the venous circulation occurs(1-12시간의 지연)
1. cTnT(cardiac-specific troponin), cTnI(cardiac-specific troponin I)
skeleton muscle의 amino sequence와 달라 특이도 높다.
정상인에서는 검출되지 않으나 >20times higher in STEMI
UA from NSTEMI진단에도 사용(small MI, sleletal muscle injury)
STEMI 이후 7-10일 동안 지속
2. CK(creatine phosphokinase)
rises within 4-8h, generally returns to normal by 47-72h
특이도 낮다(skeletal muscle dz or trauma에서 증가)
CK-MB isoenzyme: significant concentrations in extracardiac tissue(특이도높다)
CK-MB2(심근):CK-MB1>1.5일 때 AMI를 시사(onset 후 2시간부터 검출, 4-6h까지 MI diagnosis 민감도, 특이도 높다)
소개글