항암제의 분류 및 약리작용

본문내용

1. Antineoplastic Drug
1) Alkylating agent
(1) Classic alkylators
① Cyclosphamide (Cytoxan, CTX)
- indication : leukemia, lymphoma, multiple myeloma, neuroblastoma,
brest ca, ovarian, lung cancer.
- 약물 동력학 : good oral absorption
hepatic metabolisim → 4-hydroxycyclophosphamide(active matebolite)
- 부산물( urotoxic metabolite, hemorrhagic cystitis)
- toxicity: hemorrhagic cystitis → adequate hydration,
frequent urinary voiding.
mesna (EPS, high dose in BMT)

키워드

Chemo,   항암제 분류와 약리,   항암제