임신중 고혈압 Hypertensive Disorders in Pregnancy
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목차

서 론
정의 및 분류
위험인자(risk factors)
원인 및 병인
1. uteroplacental circulation
1) Vascular endothelial growth factor(VEGF) and the vascular adhesion phenotype of invading cytotrophoblasts
2) Decidual extracelluar matrix and cell surface adhesion molecules
2. Vascular tone regulation
3. Pathogenesis of Preeclampsia
4. Etiology of Preeclampsia
1) placental ischemia
2) very low-density lipoproteins(VLDL) versus toxicity-preventing activity(TxPA)
3) Immune maladaptation
4) Preeclampsia as a genetic disease
5) 최근에 제시되고 있는 이론들(recent theories)

5. Unifying Hypothesis

예 방
1. Calcium for Preecalmpsia Prevention(CPEP) trial
2. CLASP(Collaborative Low-Dose Aspirin Study in Pregnancy) trial
3. 이외에 Zinc, Magnesium, omega-3-fatty acids 등이 자간전증의 예방에 도움이 된다고 제시되고 있지만 아직은 증명되지 않은 상태이다.60)

치 료
1. 경증 자간전증의 치료
2. 중증 자간전증의 치료
3. MgSO4의 치료효과 및 부작용

결 론

본문내용

in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 1997;89:403-408.
45. Vigne J-L, Murai JT, Arbogast BW, Jia W, Fisher SJ, Taylor RN. Elevated nonesterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin. J Clin Endocrinol Metab 1997;82:3786-3792.
46. Campbell DM, MacGillivray I, Carr Hill R. Preeclampsia in secondary pregnancy. Br J Obstet Gynecol 1985;92:131-140.
47. van Beek E, Peeters LLH. Pathogenesis of preeclampsia: A comprehensive model. Obstet Gynecol Surv 1998;53:233-239.
48. Carosella ED, Dausset J, Kirszenbaum M. HLA-G revisited. Immunol Today 1996;17:407-9.
49. Colbern GT, Chiang MH, Main EK. Expression of the nonclassic histoco- mpatibility antigen HLA-G by preelamptic placenta. Am J Obstet Gynecol 1994;170:1244-50.
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51. Chesley LC, Annitto JE, Cosgrove RA. The familial factor in toxemia of pregnancy. Obstet Gynecol 1968;32:303-11.
52. Arngrimsson R, Connor JM, Geirsson RT, Brennecke S, Cooper DW. Is genetic susceptibility for preeclampsia and eclampsia associated with implantation failure and fetal demise? Lancet 1994;343:1643-4.
53. Kilpatrick DC, Gibson F, Livingston J, Liston WA. Preeclampsia is associated with HLA-DR4 sharing between mother and fetus. Tissue Antigens 1990;35:178-8.
54. Ward K, Hata A, Jeunemaitre X. A molecular variant of angiotensinogen associated with preeclampsia. Nature Genet 1993;4:59-61.
55. 조용균. 한국인 자간전증 임신부의 angiothesinogen exon 2 M235 유전자의 변이. 1995. 의학박사학위논문.
56. Widschwendter M, Schrocksnadel H, Mortl MG. Preeclampsia: a disorder of placental mitochondria? Mol Med Today 1998;July:286-291
57. Redman CWG, Sacks GP, Sargent IL. Preeclampsia: An excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506.
58. Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD. et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997;337:69-76.
59. Collaborative Group: CLASP: A randomized trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant women. Lancet 1994; 343:619-629.
60. Repke JT, Robinson JN. The prevention and management of preeclampsia and eclampsia. Int J Gynecol Obstet 1998;62:1-9.
61. Schiff E, Friedman SA, Sibai BM. Conservative management of severe preeclampsia remote from term. Obstet Gynecol 1994; 84: 626-630.
62. Linton DM, Anthony J. Critical care management of severe preeclampsia. Intensive Care Med 1997;23:248-255.
63. Hsueh WA. Preeclampsia and hypertension in pregnancy. Current Therapy in Endocrinology and Metabolism. 1997;6:324-327.
64. Witilin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998;92:883-9.
65. Repke JT. Preeclampsia and hypertension. In: Repke JT, editor. Intrapartum Obstetrics. New York: Churchill Livingstone, 1996:253-273.

키워드

자궁,   난소,   출산,   혈압,   임신,   중절,   태아,   합병증
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  • 페이지수25페이지
  • 등록일2004.05.22
  • 저작시기2004.05
  • 파일형식한글(hwp)
  • 자료번호#252085
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