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toxicity precipitated by concomitant use of citalopram and methylene blue. Med J Aust 2008;189:534.
[70] Boyer EW, Shannon M. The serotonin syndrome. N Engl JMed 2005;352:1112. 20.
[71] Parlow JL, van Vlymen JM. The methylene blues: anticipating adverse reactions to non-anesthetic drugs. Can J Anaes
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drug으로 인한 mucositis가 잘 생기는 drug과 management
1) Drug: MTX, actinomycin-D, 5-FU
2) Management
① Warm saline rises, viscous lidocain
② IV fluid, hyperalimentation
③ Oral candida: clotrimazile, amphotericin B
④ HSV: IV acyclovir
48. Pulmonary toxicity를 시사하는 소견
1) DLCo < 40% ofo
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toxicity precipitated by concomitant use of citalopram and methylene blue. Med J Aust 2008;189:534.
[70] Boyer EW, Shannon M. The serotonin syndrome. N Engl JMed 2005;352:1112. 20.
[71] Parlow JL, van Vlymen JM. The methylene blues: anticipating adverse reactions to non-anesthetic drugs. Can J Anaes
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Drugs
Route
Toxicities
Alkylating agents
Nitrogen mustard
Cyclophosphamide
Busulfan
Dacarbazine
Cisplatin
IV, IA
PO, IV, IM
PO, IV
IV, IA
IV, IP
N&V, M, A
N&V, M, cystitis, infertility
N&V, M, infertility, pigmentation
N&V, M, flu-like, A, urticaria
N&V, M, renal & oto toxicity
Antibiotics
Dactinom
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cancer.
- 약물 동력학 : good oral absorption
hepatic metabolisim → 4-hydroxycyclophosphamide(active matebolite)
- 부산물( urotoxic metabolite, hemorrhagic cystitis)
- toxicity: hemorrhagic cystitis → adequate hydration,
frequent urinary voiding.
mesna (EPS, high dose in BMT)&nbs
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