목차
I. 서 론
Ⅱ. 본론
1. 노화에 따른 면역퇴화
2. 면역퇴화와 운동
Ⅲ. 결 론
Ⅱ. 본론
1. 노화에 따른 면역퇴화
2. 면역퇴화와 운동
Ⅲ. 결 론
본문내용
nology, 55, 677.
Shinkai, S., Kohno, H., Kimura, K., Komura, K., Asai, H., Inai, R., Oka, K., Kurokawa, Y., & Shephard, R.J.(1995). Physical activity and immune senescence in men. Med. Sci. Sports Exerc. 27L, 1516-1526.
Smith, K.A., Crahbtree. G.R., Kenned, S.J., & Munick, A.V.(1977). Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unsti- mulated human lymphocytes, Nature(London). 267, 523.
Smith DJ, Ebersole JL, Taubman MA. (1983). Local and systemic immune response in aged ham- sters. Immunol, 50, 407.
Sonntag. W.E.(1987). Hormone sec- retion and action in aging animals and mans, Rev. Biol. Res. Aging, 3. 299.
Strom, T.B., Lundin, A.P., & Carpenter, C.B.(1977). The role of cyclic nucleotides in lym- phocyte activation and function, Prog. Clin. Immunol., 3, 115.
Thoman, M.L. & Weigle, W.O. (1985). reconstitution of in vivo cellmediated lympholysis res- ponses in aged mice with interlcukin 2. J. Immunol., 134, 949.
Thomna, M.L. & Weigle, W.O. (1988). Partial restoration of Con A-induced proliferation IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin, Cell Immunol., 114, 1.
Umezawa. M., Hanada, K., Naiki, H., Chen, W., Hosokawa, M., Hosono. M., Hosokawa, T., & Takeda, T.(1990). Effects of dietary restriction on age- related immune dysfunction in the senescence accelerated mouse (SAM). J. Nutri., 120, 1393.
Utsuyama, M., Kasai, M., Kura- shima, C., & Hirokawa, K. (1991). Age influence on the thymic capacity to promote differentiation of T cells: inductionof different compo- sition of T cell subsets by aging thymus, Mech. Aging Dev., 58, 267.
ABSTRACT
The Effectes of Exercise on Aging-related Immune System Change
Oh, Youn-Sun Lee, Bae-Ik
Human immune function undergoes adverse changes with aging, including development of a relative immune deficiency and on immune dysregulated state. The T cells show the largest a age-related differences in distribution and function. The antibody production capacity of B cells also shows an age-related decline. Only a few studies have compared the immune response of young and older individuals to acute exercise. Actue bouts of exercise modulate many immune parameters as seen in peripheral blood. With regard to NK cell activity, a single bout of moderate exerise seems to be well tolerated by the elderly, and the resting NK cell activity of elderly subjects seems to increase with training. Cross-sectional comparisons of immune status imply that habitual physical activity may enhance NK cell activity and check certain aspects of the age-related decline in T cell function. Future studies are required to clarify whether such long-term exercise and resulting impro- vements of immune function give rise to any beneficial effects on infections, malignancies, and autoimmune disorders. And An effective method for preventing or age-related decline in immune function would have considerable impact on clinical and public health.
Shinkai, S., Kohno, H., Kimura, K., Komura, K., Asai, H., Inai, R., Oka, K., Kurokawa, Y., & Shephard, R.J.(1995). Physical activity and immune senescence in men. Med. Sci. Sports Exerc. 27L, 1516-1526.
Smith, K.A., Crahbtree. G.R., Kenned, S.J., & Munick, A.V.(1977). Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unsti- mulated human lymphocytes, Nature(London). 267, 523.
Smith DJ, Ebersole JL, Taubman MA. (1983). Local and systemic immune response in aged ham- sters. Immunol, 50, 407.
Sonntag. W.E.(1987). Hormone sec- retion and action in aging animals and mans, Rev. Biol. Res. Aging, 3. 299.
Strom, T.B., Lundin, A.P., & Carpenter, C.B.(1977). The role of cyclic nucleotides in lym- phocyte activation and function, Prog. Clin. Immunol., 3, 115.
Thoman, M.L. & Weigle, W.O. (1985). reconstitution of in vivo cellmediated lympholysis res- ponses in aged mice with interlcukin 2. J. Immunol., 134, 949.
Thomna, M.L. & Weigle, W.O. (1988). Partial restoration of Con A-induced proliferation IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin, Cell Immunol., 114, 1.
Umezawa. M., Hanada, K., Naiki, H., Chen, W., Hosokawa, M., Hosono. M., Hosokawa, T., & Takeda, T.(1990). Effects of dietary restriction on age- related immune dysfunction in the senescence accelerated mouse (SAM). J. Nutri., 120, 1393.
Utsuyama, M., Kasai, M., Kura- shima, C., & Hirokawa, K. (1991). Age influence on the thymic capacity to promote differentiation of T cells: inductionof different compo- sition of T cell subsets by aging thymus, Mech. Aging Dev., 58, 267.
ABSTRACT
The Effectes of Exercise on Aging-related Immune System Change
Oh, Youn-Sun Lee, Bae-Ik
Human immune function undergoes adverse changes with aging, including development of a relative immune deficiency and on immune dysregulated state. The T cells show the largest a age-related differences in distribution and function. The antibody production capacity of B cells also shows an age-related decline. Only a few studies have compared the immune response of young and older individuals to acute exercise. Actue bouts of exercise modulate many immune parameters as seen in peripheral blood. With regard to NK cell activity, a single bout of moderate exerise seems to be well tolerated by the elderly, and the resting NK cell activity of elderly subjects seems to increase with training. Cross-sectional comparisons of immune status imply that habitual physical activity may enhance NK cell activity and check certain aspects of the age-related decline in T cell function. Future studies are required to clarify whether such long-term exercise and resulting impro- vements of immune function give rise to any beneficial effects on infections, malignancies, and autoimmune disorders. And An effective method for preventing or age-related decline in immune function would have considerable impact on clinical and public health.