DNA repair와 cancer

소개글

DNA repair와 cancer에 대한 보고서 자료입니다.

목차

-The balance of life

-DNA damage and responses

-DNA damage and repair

-Direct repair - photolyase

-Direct repair - MGMT

-Mismatch repair (MMR)

-Nucleotide excision repair (NER)

-Base excision repair (BER)

-Homologous recombinational repair (HR)

-Non-homologous end joining (NHEJ)

-Human cancer susceptibility linked to DNA-damage response

본문내용

3-Methyladenine-DNA-glycosylase Methylatedbases with destabilized glycosylbonds, such as N3-methyladenine (shown as –N–CH3) are excised by 3-methyladenine (3-meA)-DNA-glycosylase(blue). Several additional activities are required to completerepair of the resulting abasicsites. An apurinicendonucleaseincises the baseless site, aDNA polymerase inserts a single nucleotide and a DNA ligaseseals the single strandedgap. This pathway,whichis initiated by a DNA-glycosylase, is known as base excisionrepair.

키워드

DNA,   repair,   cancer,   DNA 수리,   암,   DNA damage,   DNA 손상