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and potential as an early means of severity assessment in acute pancreatitis. Gut 34:41-44, 1993
37.Exley AR, Leese T, Holliday MP, Swann RA, Cohen J, Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis. Gut 33:1126-1128, 1992
38.Panozzo MP, Basso D, Fabr
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and HPA axis.
Future areas of research intrest include activation or modulation of leptin receptors and overcomming leptin resistance with high pharmacological doses of leptin or its congeners. All of these objectives are still somewhat elusive, and a lot of research needs to be weaved together to a
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and the Extrinsic Pathway
1. Death Receptor
2. Death ligand
3. signal transduction
The mitochondria apoptosis pathway.
1.The Mitochondria
2.Apoptosis signaling pathway
3.Structure and channel forming activity of the Bcl-2 protein proteins
4.Activation of the pro-apoptotic multidomain Bc
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b. Hypothesis for the association of SLE with genetic deficiencies
(a) The clearance hypothesis states
(b) The tolerance hypothesis states
D. Therapy
a. Pharmacotherapy
b. Natural treatment
c. Gene therapy
① TGF-b1, a potent anti-inflammatory cytokine
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and chlorophenol production workers and sprayers. Environ. Health Perspect., 106 (Suppl 2), 645-653, 1998
Veronesi, B., OOrtgiesen, M., Carter, J.D., and Devlin, R.B.; Particulate matter initiates inflammatory cytokine release by activation of capsaicin and acid receptors in a human bronchial epithe
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and resulting impro- vements of immune function give rise to any beneficial effects on infections, malignancies, and autoimmune disorders. And An effective method for preventing or age-related decline in immune function would have considerable impact on clinical and public health. I. 서 론
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genesis
Change of chromatin structure
Silencing of tumor suppressor gene(p53)
Reactivation of tumorigenesis genes(angiogenic factor)
Tumorigenesis
HDAC 결합인자
Mi-2β(chromatin remodeling factor)
MTA(metastasis-associated factors)
HAT,HDAC mechanism
HDAC isotypes
Class I - Rpd3 와 유사
H
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and C, which are located on the same chromosome
- About 300 different V gene-segments, 4 different J gene-segments, 1 copy in C gene-segment
- In embryonic cell, V segments form a tight cluster, J segments form a second cluster, and the C segment follows after J segment.
- Each V gene-segment is pre
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조모색 후보유전자로 KIT유전자가 제시되고 있는데 이것은 말의 조모색이 KIT에 의해 조절되고 있음을 강하게 시사하고 있다. Introduction
Materials and Methods
Discussion - Cattle case
Discussion - Horses case
Discussion - Swine case
References
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genesis를 방해하는 물질을 분비하여 metastatic tumor의 증식을 방해
: Angiostatin, Endostatin, Troponin I, Prostate Specific Antigen (PSA)
: Synthetic angiogenesis inhibitors
- monoclonal antibody directed against the anb3 vascular integrin
- Anti-VEGF
5) Glyvec (STI571)
. CML 치료제 (만성 골수
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